Increased interleukin-1β levels following low dose MDMA induces tolerance against the 5-HT neurotoxicity produced by challenge MDMA
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منابع مشابه
MDMA -induced neurotoxicity in rats
Ž . Ž . The role of nitric oxide NO in the long-term serotoninergic neurotoxicity induced by " 3,4-methylenedioxymethamphetamine Ž . v Ž . Ž y1. Ž . MDMA in rats was investigiated. Pretreatment with N -nitro-L-arginine L-NOARG 10 mg kg , a nitric oxide synthase NOS Ž . Ž y1. inhibitor, partially protected against long-term serotonin 5-HT depletion induced by MDMA 40 mg kg in frontal cortex and ...
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amphetamine analogue that produces euphoric and stimulant effects and a feeling of closeness towards others. For more than a decade, MDMA (colloquially known as “Ecstasy” or “E”) has been widely used by young adults as a dance-party drug. The usual recreational oral dose is 1–2 tablets (each containing about 60–120 mg of MDMA) a standard oral dose of 0·75–4·00 mg per kg in 60–80 kg people. MDMA...
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Readers of the MAPS newsletter may have come across recent articles in the media claiming that new evidence shows that MDMA may cause permanent and potentially harmful brain changes even in typical recreational doses. As in most other news reports involving research about illegal drugs, the stories oversimplified the scientific findings, took data out of context, exaggerated the dangers, and ig...
متن کاملRepeated adolescent 3,4-methylenedioxymethamphetamine (MDMA) exposure in rats attenuates the effects of a subsequent challenge with MDMA or a 5-hydroxytryptamine(1A) receptor agonist.
Adolescent users of 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) may escalate their dose because of the development of tolerance. We examined the influence of intermittent adolescent MDMA exposure on the behavioral, physiological, and neurochemical responses to a subsequent MDMA "binge" or to a 5-hydroxytryptamine(1A) (5-HT(1A)) receptor challenge. Male Sprague-Dawley rats were given MDMA ...
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The majority of MDMA (ecstasy) recreational users also consume cannabis. Despite the rewarding effects that both drugs have, they induce several opposite pharmacological responses. MDMA causes hyperthermia, oxidative stress and neuronal damage, especially at warm ambient temperature. However, THC, the main psychoactive compound of cannabis, produces hypothermic, anti-inflammatory and antioxidan...
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ژورنال
عنوان ژورنال: Journal of Neuroinflammation
سال: 2011
ISSN: 1742-2094
DOI: 10.1186/1742-2094-8-165